Rarebase

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Senior Director/Director, High Throughput Biology

  • Science
  • Full-time
  • Palo Alto, CA

Overview

Rarebase is an early-stage biotechnology public benefit corporation based in Palo Alto, California working to advance personalized medicine for the thousands of genetic diseases that have no effective treatments. We operate at the intersection of technology and biology, collaborating closely with patient communities to ensure that drug discovery and development is aligned with our shared goals - to bring effective treatments to the clinic as quickly and safely as possible.

Our Function™ drug and target discovery platform integrates cellular modeling of disease with functional genomics, high throughput screening, high content imaging and computational biology to identify molecules that address the underlying biology of genetic diseases. To support Function’s rapid growth, we are building a next-generation automated lab and are recruiting a San Francisco Bay Area-based scientific team to be intimately involved in its development.

Rarebase is backed by top-tier institutional investors, pharma and biotech angel investors, families personally affected by rare disease, and others that truly care about our mission to re-invent therapeutic development for genetic diseases. Our advisors are leaders in the biotech and genetic disease community.

The Opportunity

We’re looking for a Senior Director/Director, High Throughput Biology to lead the development of the Function™ platform and oversee our High Throughput Biology function.

The ideal candidate will have extensive experience with the application of high content technologies (e.g. NGS, imaging) in the context of cell-based high throughput screening. Additionally the candidate will have in-depth expertise with regard to target ID, validation and MOA characterization. You will play an instrumental role in helping to develop our R&D strategy, and to lead an outstanding team of scientists focused on conducting inventive and innovative science that will lead to the discovery of novel medicines. 

This candidate will also work closely with our CSO and broader scientific team to build out the lab facility that will house the development of this work.

This highly visible role will manage and support external research collaborations with patient organizations and contract research organizations. You’ll be a great candidate if you are excited to facilitate the advancement of rare disease programs to the clinic and are willing to think outside the box about how best to move opportunities to this stage.

What you’ll do

  • Lead a team that uses NGS and imaging-based technologies at scale for high throughput screening and lead generation 

  • Implement deep capabilities in the use of iPSCs and patient-derived cells to create highly relevant cellular models of rare, genetically-defined diseases.

  • Contribute creatively to the company’s R&D strategy, helping drive actionable drug discovery hypotheses from the data.

  • Champion ideas for new target discovery and technology development projects.

  • Work independently with external labs to initiate and execute scientific research projects and/or development strategies.

  • Collaborate with research associates, automation specialists, and pre-clinical development teams.

  • Partner closely with the Computational Biology team to create and evolve the Function™ database

  • Develop and maintain relationships with patient organization collaborators Communicate data and scientific results to both internal and external audiences with a high degree of sophistication.


What you’ll bring

  • A Ph.D. in pharmacology or related discipline

  • 8-10 years of experience in an industry setting 

  • Track record of inventive and innovative drug discovery/target ID and ability to work as a member of a highly productive, cutting edge, multi-disciplinary team

  • Experience managing and developing direct reports 

  • Demonstrated ability to train others in the successful implementation of new technologies and the execution of new assays and screens

  • A relentless drive and curiosity coupled with great resilience and adaptability 

Physical Requirements

  • This person will need to be in the lab in Palo Alto, CA up to five days a week.

  • Prolonged periods of standing or sitting at the laboratory bench.

  • In lab and lab support activities may require occasional maneuvering of items of 25 lbs. during operations and/or storage of consumables.

What we offer

  • An opportunity to work closely with patient organizations on translational research.

  • Premium health, dental, and vision insurance

  • Competitive salary and equity in a growing, well-funded startup

  • Generous vacation policy